{"id":202145,"date":"2025-10-28T12:07:34","date_gmt":"2025-10-28T15:07:34","guid":{"rendered":"https:\/\/controllab.com\/ensino\/resumos-cientificos\/progresso-no-diagnostico-de-hiv-uma-revisao-de-14-anos-do-desempenho-e-da-qualidade-dos-testes-no-ponto-de-cuidado\/"},"modified":"2025-10-30T10:46:26","modified_gmt":"2025-10-30T13:46:26","slug":"progress-in-hiv-diagnostics-a-fourteen-year-review-of-point-of-care-testing-performance-and-quality-assessment","status":"publish","type":"resumos","link":"https:\/\/controllab.com\/en\/learning\/scientific-abstracts\/progress-in-hiv-diagnostics-a-fourteen-year-review-of-point-of-care-testing-performance-and-quality-assessment\/","title":{"rendered":"Progress in HIV Diagnostics: A Fourteen-Year Review of Point-of-Care Testing Performance and Quality Assessment"},"content":{"rendered":"\t\t<div data-elementor-type=\"wp-post\" data-elementor-id=\"202145\" class=\"elementor elementor-202145 elementor-201568\" data-elementor-post-type=\"resumos\">\n\t\t\t\t<div class=\"has_ae_slider elementor-element elementor-element-14deb9a e-flex e-con-boxed ae-bg-gallery-type-default e-con e-parent\" data-id=\"14deb9a\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t\t\t<div class=\"elementor-element elementor-element-4042968 elementor-widget elementor-widget-heading\" data-id=\"4042968\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<h4 class=\"elementor-heading-title elementor-size-default\">Background - Aim<\/h4>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"has_ae_slider elementor-element elementor-element-2075863 e-flex e-con-boxed ae-bg-gallery-type-default e-con e-parent\" data-id=\"2075863\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t\t\t<div class=\"elementor-element elementor-element-b0585e7 elementor-widget elementor-widget-text-editor\" data-id=\"b0585e7\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p align=\"justify\">HIV infection remains a critical global public health issue, affecting approximately 38 million individuals worldwide, with a significant burden in sub-Saharan Africa and Southeast Asia. Antibody-based rapid and point-of-care tests (POCT) for HIV (anti-HIV) are key tools in expanding access to diagnostics, particularly in resource-limited settings. External Quality Assessment Programs (EQAP) are essential to ensure these diagnostic methods&#8217; accuracy, reliability, and harmonization. This study aims to assess the diagnostic proficiency of laboratories participating in an EQAP for anti-HIV POCT, which was conducted by a Brazilian provider accredited to ABNT NBR ISO\/IEC 17043:2011.<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"has_ae_slider elementor-element elementor-element-691183f e-flex e-con-boxed ae-bg-gallery-type-default e-con e-parent\" data-id=\"691183f\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t\t\t<div class=\"elementor-element elementor-element-45d35b9 elementor-widget elementor-widget-heading\" data-id=\"45d35b9\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<h4 class=\"elementor-heading-title elementor-size-default\">Methods<\/h4>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"has_ae_slider elementor-element elementor-element-7a5a2df e-flex e-con-boxed ae-bg-gallery-type-default e-con e-parent\" data-id=\"7a5a2df\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t\t\t<div class=\"elementor-element elementor-element-15515ed elementor-widget elementor-widget-text-editor\" data-id=\"15515ed\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p align=\"justify\">Data from 2010 to 2024 were analyzed, encompassing four annual rounds. Participants tested four lyophilized and\/or liquid quality control samples per round. The metrics evaluated included the number of participants, testing methods, adequacy rates (%A), specificity (SP), and sensitivity (SE).<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"has_ae_slider elementor-element elementor-element-5278660 e-flex e-con-boxed ae-bg-gallery-type-default e-con e-parent\" data-id=\"5278660\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t\t\t<div class=\"elementor-element elementor-element-f82c5ca elementor-widget elementor-widget-heading\" data-id=\"f82c5ca\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<h4 class=\"elementor-heading-title elementor-size-default\">Results<\/h4>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"has_ae_slider elementor-element elementor-element-b077eea e-flex e-con-boxed ae-bg-gallery-type-default e-con e-parent\" data-id=\"b077eea\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t\t\t<div class=\"elementor-element elementor-element-cf04e42 elementor-widget elementor-widget-text-editor\" data-id=\"cf04e42\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p>928 laboratories contributed 58,409 datasets, including 903 from Brazil and 25 from Bolivia, Colombia, and Panama. Laboratory participation increased significantly, from 82 in 2010 to 365 in 2024 (p=0.0000), and consolidated in more than 300 since 2021. Performance metrics were consistently high, with an overall %A of 98.6%, SP of 98.9%, and SE of 98.5% (Figure 1). Immunochromatography was the predominant testing method, achieving %A 98.7%, SP 98.9%, SE 98.5%, 99% true-negative results, and 98.1% true-positive results. Performance by the most commonly used kits was as follows:<\/p><ul><li>Manufacturer A: 375 participants, 13,755 datasets, %A 99.4%, SP 99.6%, SE 99.1%<\/li><li>Manufacturer B: 298 participants, 8,464 datasets, %A 99.1%, SP 99.6%, SE 97.8%<\/li><li>Manufacturer C: 165 participants, 4,145 datasets, %A 98.5%, SP 98.5%, SE 98.6%<\/li><\/ul>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"has_ae_slider elementor-element elementor-element-93130e7 e-flex e-con-boxed ae-bg-gallery-type-default e-con e-parent\" data-id=\"93130e7\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t\t\t<div class=\"elementor-element elementor-element-bd93a87 elementor-widget elementor-widget-image\" data-id=\"bd93a87\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"image.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t\t\t\t<figure class=\"wp-caption\">\n\t\t\t\t\t\t\t\t\t\t\t<a href=\"https:\/\/controllab.com\/wp-content\/uploads\/Artigo-4-Figura-1.png\" data-elementor-open-lightbox=\"yes\" data-e-action-hash=\"#elementor-action%3Aaction%3Dlightbox%26settings%3DeyJpZCI6MjAxNTc4LCJ1cmwiOiJodHRwczpcL1wvY29udHJvbGxhYi5jb21cL3dwLWNvbnRlbnRcL3VwbG9hZHNcL0FydGlnby00LUZpZ3VyYS0xLnBuZyJ9\">\n\t\t\t\t\t\t\t<img decoding=\"async\" width=\"231\" height=\"149\" src=\"https:\/\/controllab.com\/wp-content\/uploads\/Artigo-4-Figura-1.png\" class=\"attachment-large size-large wp-image-201578\" alt=\"Participa\u00e7\u00e3o e desempenho ao longo do tempo - Figura 1\" srcset=\"https:\/\/controllab.com\/wp-content\/uploads\/Artigo-4-Figura-1.png 231w, https:\/\/controllab.com\/wp-content\/uploads\/Artigo-4-Figura-1-116x75.png 116w\" sizes=\"(max-width:767px) 231px, 231px\" \/>\t\t\t\t\t\t\t\t<\/a>\n\t\t\t\t\t\t\t\t\t\t\t<figcaption class=\"widget-image-caption wp-caption-text\">Figure 1: Participation and performance over time.<\/figcaption>\n\t\t\t\t\t\t\t\t\t\t<\/figure>\n\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"has_ae_slider elementor-element elementor-element-3bd60cd e-flex e-con-boxed ae-bg-gallery-type-default e-con e-parent\" data-id=\"3bd60cd\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t\t\t<div class=\"elementor-element elementor-element-dbc2768 elementor-widget elementor-widget-image\" data-id=\"dbc2768\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"image.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t\t\t\t<figure class=\"wp-caption\">\n\t\t\t\t\t\t\t\t\t\t\t<a href=\"https:\/\/controllab.com\/wp-content\/uploads\/Artigo-4-Tabela-1-1.png\" data-elementor-open-lightbox=\"yes\" data-e-action-hash=\"#elementor-action%3Aaction%3Dlightbox%26settings%3DeyJpZCI6MjAxNTgxLCJ1cmwiOiJodHRwczpcL1wvY29udHJvbGxhYi5jb21cL3dwLWNvbnRlbnRcL3VwbG9hZHNcL0FydGlnby00LVRhYmVsYS0xLTEucG5nIn0%3D\">\n\t\t\t\t\t\t\t<img fetchpriority=\"high\" decoding=\"async\" width=\"579\" height=\"125\" src=\"https:\/\/controllab.com\/wp-content\/uploads\/Artigo-4-Tabela-1-1.png\" class=\"attachment-large size-large wp-image-201581\" alt=\"Desempenho dos kits mais comumente usados - Tabela 1\" srcset=\"https:\/\/controllab.com\/wp-content\/uploads\/Artigo-4-Tabela-1-1.png 579w, https:\/\/controllab.com\/wp-content\/uploads\/Artigo-4-Tabela-1-1-150x32.png 150w, https:\/\/controllab.com\/wp-content\/uploads\/Artigo-4-Tabela-1-1-480x104.png 480w, https:\/\/controllab.com\/wp-content\/uploads\/Artigo-4-Tabela-1-1-500x108.png 500w\" sizes=\"(max-width:767px) 480px, 579px\" \/>\t\t\t\t\t\t\t\t<\/a>\n\t\t\t\t\t\t\t\t\t\t\t<figcaption class=\"widget-image-caption wp-caption-text\">Table 1: Performance of most commonly used kits:<\/figcaption>\n\t\t\t\t\t\t\t\t\t\t<\/figure>\n\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"has_ae_slider elementor-element elementor-element-5e5a065 e-flex e-con-boxed ae-bg-gallery-type-default e-con e-parent\" data-id=\"5e5a065\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t\t\t<div class=\"elementor-element elementor-element-f08aa96 elementor-widget elementor-widget-heading\" data-id=\"f08aa96\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<h4 class=\"elementor-heading-title elementor-size-default\">Conclusions<\/h4>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"has_ae_slider elementor-element elementor-element-045a415 e-flex e-con-boxed ae-bg-gallery-type-default e-con e-parent\" data-id=\"045a415\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t\t\t<div class=\"elementor-element elementor-element-cc438b8 elementor-widget elementor-widget-text-editor\" data-id=\"cc438b8\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p align=\"justify\">This study demonstrates the growing adoption of anti-HIV POCT in Brazil and neighboring countries, as evidenced by significant increases in EQAP enrollment and consistently high-performance metrics. These findings underscore the reliability and effectiveness of anti-HIV POCT detection and highlight the pivotal role of EQAPs in maintaining diagnostic accuracy and advancing quality standards across the region.<\/p><p align=\"justify\">\u00a0<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"has_ae_slider elementor-element elementor-element-1530fff e-flex e-con-boxed ae-bg-gallery-type-default e-con e-parent\" data-id=\"1530fff\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t\t\t<div class=\"elementor-element elementor-element-61c5b44 elementor-widget elementor-widget-heading\" data-id=\"61c5b44\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<h4 class=\"elementor-heading-title elementor-size-default\">References<\/h4>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"has_ae_slider elementor-element elementor-element-50b172f e-flex e-con-boxed ae-bg-gallery-type-default e-con e-parent\" data-id=\"50b172f\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t\t\t<div class=\"elementor-element elementor-element-bcb62a7 elementor-widget elementor-widget-text-editor\" data-id=\"bcb62a7\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p align=\"justify\"><span style=\"font-family: Arial, serif;\"><span lang=\"en-US\">Di Germanio C, Yufenyuy EL, Hampton DC, Thorbrogger C, Parekh BS, Norris PJ. A Stable Dried Tube Specimen for Quality Assurance and Training Programs for HIV Rapid Test for Recent Infection. Microbiol Spectr. 2023 Feb 14;11(1): e0339822. doi:10.1128\/spectrum.03398-22. Epub 2023 Jan17. PMID:36648237; PMCID: PMC9927143.<\/span><\/span><\/p><p align=\"justify\"><span style=\"font-family: Arial, serif;\"><span lang=\"en-US\">Smallwood M, Vijh R, Nauche B, Lebouch\u00e9 B, Joseph L, Pant Pai N. Evaluation of a Rapid Point of Care Test for Detecting Acute and Established HIV Infection, and Examining the Role of Study Quality on Diagnostic Accuracy: A Bayesian MetaAnalysis. PLoS One. 2016 Feb18;11(2): e0149592. doi: 10.1371\/journal.pone. 0149592. PMID:26891218; PMCID: PMC4758636.<\/span><\/span><\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t","protected":false},"excerpt":{"rendered":"<p>A. Ferreira4, L. Bottino1, J. Gomes1, A. Vieira1, J. Casali1, E. Mesquita1, S. Da Silva1, T. Aguiar1, L. Vasconcellos2, \u00c1. Pulchinelli3, R. Sykora4, J. Poloni1, V. Biasoli1<\/p>\n","protected":false},"template":"","meta":{"_acf_changed":false},"tags":[2772,2773,2774],"class_list":["post-202145","resumos","type-resumos","status-publish","hentry","tag-diagnostico-de-hiv","tag-ponto-de-cuidado","tag-qualidade-dos-testes"],"acf":[],"_links":{"self":[{"href":"https:\/\/controllab.com\/en\/wp-json\/wp\/v2\/resumos\/202145","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/controllab.com\/en\/wp-json\/wp\/v2\/resumos"}],"about":[{"href":"https:\/\/controllab.com\/en\/wp-json\/wp\/v2\/types\/resumos"}],"wp:attachment":[{"href":"https:\/\/controllab.com\/en\/wp-json\/wp\/v2\/media?parent=202145"}],"wp:term":[{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/controllab.com\/en\/wp-json\/wp\/v2\/tags?post=202145"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}