{"id":201677,"date":"2025-10-28T14:33:14","date_gmt":"2025-10-28T17:33:14","guid":{"rendered":"https:\/\/controllab.com\/?post_type=resumos&#038;p=201677"},"modified":"2025-10-28T14:43:28","modified_gmt":"2025-10-28T17:43:28","slug":"desempenho-laboratorial-na-deteccao-molecular-de-hpv-de-alto-e-baixo-risco-ensaios-de-alto-risco-superam-o-desempenho-de-ensaios-de-baixo-risco","status":"publish","type":"resumos","link":"https:\/\/controllab.com\/es\/educacion\/resumenes-cientificos\/desempenho-laboratorial-na-deteccao-molecular-de-hpv-de-alto-e-baixo-risco-ensaios-de-alto-risco-superam-o-desempenho-de-ensaios-de-baixo-risco\/","title":{"rendered":"Desempenho Laboratorial na Detec\u00e7\u00e3o Molecular de HPV de Alto e Baixo Risco: Ensaios de Alto Risco Superam o Desempenho de Ensaios de Baixo Risco"},"content":{"rendered":"\t\t<div data-elementor-type=\"wp-post\" data-elementor-id=\"201677\" class=\"elementor elementor-201677\" data-elementor-post-type=\"resumos\">\n\t\t\t\t<div class=\"has_ae_slider elementor-element elementor-element-8ab8f80 e-flex e-con-boxed ae-bg-gallery-type-default e-con e-parent\" data-id=\"8ab8f80\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t\t\t<div class=\"elementor-element elementor-element-ae64821 elementor-widget elementor-widget-heading\" data-id=\"ae64821\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<h4 class=\"elementor-heading-title elementor-size-default\">Introdu\u00e7\u00e3o - Objetivo<\/h4>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"has_ae_slider elementor-element elementor-element-43a5ba3 e-flex e-con-boxed ae-bg-gallery-type-default e-con e-parent\" data-id=\"43a5ba3\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t\t\t<div class=\"elementor-element elementor-element-1154ede elementor-widget elementor-widget-text-editor\" data-id=\"1154ede\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p align=\"justify\"><span style=\"font-family: Arial, serif;\">A detec\u00e7\u00e3o do HPV \u00e9 uma prioridade global de sa\u00fade. O HPV de alto risco (HR-HPV) \u00e9 uma das principais causas de c\u00e2ncer cervical, enquanto o HPV de baixo risco (LR-HPV) est\u00e1 associado a les\u00f5es benignas, como verrugas genitais. Testes confi\u00e1veis \u200b\u200bpara HPV exigem desempenho laboratorial padronizado, e os Programas Externos de Avalia\u00e7\u00e3o da Qualidade (PEQA) desempenham um papel vital para garantir a precis\u00e3o e a harmoniza\u00e7\u00e3o. Este estudo comparou o desempenho laboratorial em um PEQA para detec\u00e7\u00e3o molecular de HR-HPV e LR-HPV por PCR\/qPCR, organizado por um provedor credenciado pela ABNT NBR ISO\/IEC 17043:2011.<\/span><\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"has_ae_slider elementor-element elementor-element-9b6ac6a e-flex e-con-boxed ae-bg-gallery-type-default e-con e-parent\" data-id=\"9b6ac6a\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t\t\t<div class=\"elementor-element elementor-element-f1d920b elementor-widget elementor-widget-heading\" data-id=\"f1d920b\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<h4 class=\"elementor-heading-title elementor-size-default\">M\u00e9todos<\/h4>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"has_ae_slider elementor-element elementor-element-a8cb3a9 e-flex e-con-boxed ae-bg-gallery-type-default e-con e-parent\" data-id=\"a8cb3a9\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t\t\t<div class=\"elementor-element elementor-element-8092183 elementor-widget elementor-widget-text-editor\" data-id=\"8092183\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p align=\"justify\"><span style=\"font-family: Arial, serif;\">Amostras l\u00edquidas de escovado cervical ou lisado celular foram utilizadas no PEQA. Entre 2020 e 2024, os laborat\u00f3rios receberam duas amostras trimestrais para avaliar a acur\u00e1cia (AC), a sensibilidade (SE) e a especificidade (SP). Essas m\u00e9tricas de desempenho foram avaliadas e comparadas entre PCR\/qPCR para HPV de alto e baixo risco usando testes qui-quadrado e odds ratio. As tend\u00eancias de AC para HR-HPV e LR-HPV ao longo do tempo foram analisadas usando o teste de Mann-Kendall.<\/span><\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"has_ae_slider elementor-element elementor-element-550b9ac e-flex e-con-boxed ae-bg-gallery-type-default e-con e-parent\" data-id=\"550b9ac\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t\t\t<div class=\"elementor-element elementor-element-9efb892 elementor-widget elementor-widget-heading\" data-id=\"9efb892\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<h4 class=\"elementor-heading-title elementor-size-default\">Resultados<\/h4>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"has_ae_slider elementor-element elementor-element-45adac2 e-flex e-con-boxed ae-bg-gallery-type-default e-con e-parent\" data-id=\"45adac2\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t\t\t<div class=\"elementor-element elementor-element-8f80eef elementor-widget elementor-widget-text-editor\" data-id=\"8f80eef\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p align=\"justify\"><span style=\"font-family: Arial, serif;\">69 laborat\u00f3rios (mediana de 18 laborat\u00f3rios\/rodada, intervalo de 5 a 51; 692 conjuntos de dados) participaram da avalia\u00e7\u00e3o de HR-HPV e 34 laborat\u00f3rios (mediana de 12 laborat\u00f3rios\/rodada, intervalo de 2 a 26; 386 conjuntos de dados) na avalia\u00e7\u00e3o de LR-HPV. Os resultados do HR-HPV foram 97,98% (678\/692) AC, 97,79% (620\/634) SE e 100% (58\/58) ES, enquanto o LR-HPV atingiu 94,82% (366\/386) AC, 93,84% (259\/276) SE e 97,27% (107\/110) ES. Diferen\u00e7as significativas na SE (OR=2,91, IC95%: 1,41\u20135,98, p=0,0048) e AC (OR=2,62, IC95%: 1,32\u20135,19, p=0,0077) favoreceram o HR-HPV, enquanto a ES foi compar\u00e1vel (OR=3,81, IC95%: 0,19\u201375,02, p=0,5116) (Tabela 1). N\u00e3o foram observadas tend\u00eancias significativas na AC ao longo do tempo para os testes de HPV de alto risco (\u03c4 = -0,046, p = 0,795) ou de baixo risco (\u03c4 = 0,3, p = 0,098).<\/span><\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"has_ae_slider elementor-element elementor-element-78b7ed6 e-flex e-con-boxed ae-bg-gallery-type-default e-con e-parent\" data-id=\"78b7ed6\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t\t\t<div class=\"elementor-element elementor-element-1948250 elementor-widget elementor-widget-image\" data-id=\"1948250\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"image.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t\t\t\t<figure class=\"wp-caption\">\n\t\t\t\t\t\t\t\t\t\t\t<a href=\"https:\/\/controllab.com\/wp-content\/uploads\/Artigo-8-Tabela-1.png\" data-elementor-open-lightbox=\"yes\" data-e-action-hash=\"#elementor-action%3Aaction%3Dlightbox%26settings%3DeyJpZCI6MjAxNjg3LCJ1cmwiOiJodHRwczpcL1wvY29udHJvbGxhYi5jb21cL3dwLWNvbnRlbnRcL3VwbG9hZHNcL0FydGlnby04LVRhYmVsYS0xLnBuZyJ9\">\n\t\t\t\t\t\t\t<img fetchpriority=\"high\" decoding=\"async\" width=\"492\" height=\"199\" src=\"https:\/\/controllab.com\/wp-content\/uploads\/Artigo-8-Tabela-1.png\" class=\"attachment-large size-large wp-image-201687\" alt=\"Desempenho da participa\u00e7\u00e3o no programa HR-HPV versus o programa LR-HPV - Tabela 1\" srcset=\"https:\/\/controllab.com\/wp-content\/uploads\/Artigo-8-Tabela-1.png 492w, https:\/\/controllab.com\/wp-content\/uploads\/Artigo-8-Tabela-1-150x61.png 150w, https:\/\/controllab.com\/wp-content\/uploads\/Artigo-8-Tabela-1-480x194.png 480w\" sizes=\"(max-width:767px) 480px, 492px\" \/>\t\t\t\t\t\t\t\t<\/a>\n\t\t\t\t\t\t\t\t\t\t\t<figcaption class=\"widget-image-caption wp-caption-text\">Tabela 1: Desempenho da participa\u00e7\u00e3o no programa HR-HPV versus o programa LR-HPV<\/figcaption>\n\t\t\t\t\t\t\t\t\t\t<\/figure>\n\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"has_ae_slider elementor-element elementor-element-a7b2c82 e-flex e-con-boxed ae-bg-gallery-type-default e-con e-parent\" data-id=\"a7b2c82\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t\t\t<div class=\"elementor-element elementor-element-811e441 elementor-widget elementor-widget-heading\" data-id=\"811e441\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<h4 class=\"elementor-heading-title elementor-size-default\">Conclus\u00f5es<\/h4>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"has_ae_slider elementor-element elementor-element-e90bb66 e-flex e-con-boxed ae-bg-gallery-type-default e-con e-parent\" data-id=\"e90bb66\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t\t\t<div class=\"elementor-element elementor-element-b03dcb6 elementor-widget elementor-widget-text-editor\" data-id=\"b03dcb6\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p align=\"justify\"><span style=\"font-family: Arial, serif;\">Ambas as avalia\u00e7\u00f5es demonstraram forte desempenho, com o HR-HPV apresentando melhor sensibilidade e acur\u00e1cia, enquanto a especificidade foi semelhante. N\u00e3o foram observadas tend\u00eancias significativas na acur\u00e1cia ao longo do tempo, indicando estabilidade sem altera\u00e7\u00f5es ao longo do tempo. A detec\u00e7\u00e3o do LR-HPV continua sendo crucial para o manejo de les\u00f5es, permitindo um tratamento com boa rela\u00e7\u00e3o custo-benef\u00edcio, reduzindo a transmiss\u00e3o e apoiando estrat\u00e9gias de sa\u00fade p\u00fablica. Este estudo destaca que os ensaios de PCR\/qPCR para LR-HPV t\u00eam espa\u00e7o para melhorias para atender aos padr\u00f5es de HR-HPV, enfatizando a necessidade de refinamento cont\u00ednuo e avalia\u00e7\u00f5es de qualidade.<\/span><\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"has_ae_slider elementor-element elementor-element-ec7b5ce e-flex e-con-boxed ae-bg-gallery-type-default e-con e-parent\" data-id=\"ec7b5ce\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t\t\t<div class=\"elementor-element elementor-element-06c8431 elementor-widget elementor-widget-heading\" data-id=\"06c8431\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<h4 class=\"elementor-heading-title elementor-size-default\">Refer\u00eancias<\/h4>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"has_ae_slider elementor-element elementor-element-84367aa e-flex e-con-boxed ae-bg-gallery-type-default e-con e-parent\" data-id=\"84367aa\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t\t\t<div class=\"elementor-element elementor-element-5d5700b elementor-widget elementor-widget-text-editor\" data-id=\"5d5700b\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p align=\"justify\"><span style=\"font-family: Arial, serif;\"><span lang=\"en-US\">WHO guideline for screening and treatment of cervical pre-cancer lesions for cervical cancer prevention, second edition:Use of mRNA tests for human papillomavirus (HPV)-World Health Organization 2021.<\/span><\/span><\/p><p align=\"justify\"><span style=\"font-family: Arial, serif;\"><span lang=\"en-US\">Human papillomavirus (HPV) nucleic acid amplification tests (NAATs) to screen for cervical pre-cancer lesions and prevent cervical cancer: policy brief-World Health Organization 2022.<\/span><\/span><\/p><p align=\"justify\"><span style=\"font-family: Arial, serif;\"><span lang=\"en-US\">Okada PA, Mitrat S, Rojanawiwat A. External quality assessment program for human papillomaviruses DNA testing in Thailand. Pract Lab Med. 2023 Dec 26; 38: e00352. doi: 10.1016\/j.plabm. 2023. e00352. PMID: 38292923; PMCID: PMC10825476.<\/span><\/span><\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t","protected":false},"excerpt":{"rendered":"<p>G. Barra4, A. Vieira1, L. Vasconcellos2, \u00c1. Pulchinelli3, S. Lima1, C. Bastos1, F. Drummond1, V. Dias1, J. Oliveira1, J. Poloni1, V. Biasoli1<\/p>\n","protected":false},"template":"","meta":{"_acf_changed":false},"tags":[2751,2752],"class_list":["post-201677","resumos","type-resumos","status-publish","hentry","tag-desempenho-laboratorial","tag-deteccao-molecular-de-hpv"],"acf":[],"_links":{"self":[{"href":"https:\/\/controllab.com\/es\/wp-json\/wp\/v2\/resumos\/201677","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/controllab.com\/es\/wp-json\/wp\/v2\/resumos"}],"about":[{"href":"https:\/\/controllab.com\/es\/wp-json\/wp\/v2\/types\/resumos"}],"wp:attachment":[{"href":"https:\/\/controllab.com\/es\/wp-json\/wp\/v2\/media?parent=201677"}],"wp:term":[{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/controllab.com\/es\/wp-json\/wp\/v2\/tags?post=201677"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}